GLP-1s Beyond Weight Loss – The Future of Women’s Health, Fertility, Hormones, and Longevity | SXSW Panel Discussion Featuring McCall McPherson, Natalie Crawford, Jessica Shepherd & Shannon Ritchey

What if GLP-1 medications are not just changing weight loss—but completely transforming the future of women’s health?

In this special SXSW panel discussion, Shannon Ritchey moderates an eye-opening conversation with leading experts McCall McPherson, Natalie Crawford, and Jessica Shepherd about the rapidly evolving role of GLP-1 medications in fertility, thyroid health, inflammation, menopause, longevity, metabolic health, and chronic disease prevention.

This conversation goes far beyond weight loss. The panel explores how GLP-1 medications may reduce systemic inflammation, improve insulin resistance, support fertility outcomes, influence hormone health during perimenopause and menopause, protect cardiovascular health, and potentially reshape the future of longevity medicine.

The discussion also tackles common myths, cancer fears, muscle loss concerns, microdosing strategies, fertility safety, lifestyle foundations, and the importance of preserving muscle while using these medications.

🔑 Key Topics Covered

  • Why GLP-1 medications are far more than “weight loss drugs”
  • How GLP-1s improve insulin sensitivity and metabolic function
  • The powerful role GLP-1s may play in reducing systemic inflammation
  • Why microdosing GLP-1s is becoming an emerging strategy in medicine
  • The truth about thyroid cancer concerns and current research findings
  • How under-fueling and poor nutrition contribute to muscle loss on GLP-1s
  • Why strength training and protein intake are essential while using GLP-1s
  • The connection between inflammation, thyroid disease, and metabolic dysfunction
  • How GLP-1s may support fertility in women with PCOS and insulin resistance
  • Why GLP-1s should be stopped before pregnancy attempts
  • The impact of chronic inflammation on ovarian reserve and fertility outcomes
  • How GLP-1s may improve endometriosis symptoms and inflammatory reproductive conditions
  • The role of GLP-1s in perimenopause, menopause, and hormonal aging
  • Why estrogen decline impacts glucose regulation and inflammation
  • The connection between visceral fat, inflammation, and chronic disease
  • Emerging research on GLP-1s, addiction behavior, fatty liver disease, and longevity
  • Why personalized medicine and lifestyle intervention remain essential

🧠 GLP-1s Are Not Just About Eating Less

One of the strongest themes throughout the panel:

👉 GLP-1 medications are not simply making people lose weight because they eat less.

According to McCall McPherson, these medications fundamentally improve:

  • Metabolic function
  • Insulin sensitivity
  • Inflammatory pathways
  • Physiological responses to food

This is especially important for women with:

  • Thyroid dysfunction
  • PCOS
  • Autoimmune disease
  • Menopause-related metabolic changes

The panel repeatedly emphasizes:

👉 Weight gain is often not a willpower problem—it is a metabolic and inflammatory problem.

⚡ The Emerging Power of Microdosing

A major topic discussed is microdosing GLP-1s.

What Is Microdosing?

Using:

  • Much smaller doses
  • More personalized dosing strategies
  • Flexible adjustments based on symptoms and goals

Rather than aggressively increasing medication doses, microdosing may help:

  • Reduce nausea
  • Improve tolerability
  • Allow proper fueling and protein intake
  • Preserve muscle mass
  • Maintain metabolic benefits

McCall McPherson explains that many patients experience:

  • Significant inflammation reduction
  • Metabolic improvement
  • Better energy

…even at very low doses.

🔥 Inflammation: The Hidden Driver of Disease

Throughout the panel, inflammation is described as one of the biggest underlying drivers of:

  • Fertility struggles
  • Thyroid disease
  • Insulin resistance
  • Cardiovascular disease
  • Joint pain
  • Menopausal symptoms

The panelists repeatedly explain that GLP-1s appear to dramatically reduce inflammation—sometimes within days.

Why This Matters

Reducing inflammation may influence:

  • Hormonal signaling
  • Ovarian function
  • Metabolic flexibility
  • Longevity outcomes

This is one reason the panel believes GLP-1s may eventually become indicated for many conditions beyond obesity and diabetes.

🦋 Thyroid Disease, Autoimmunity & GLP-1s

McCall McPherson shares extensive clinical observations from treating thyroid patients with GLP-1s.

Key Insights Discussed

  • Significant reductions in inflammatory markers
  • Improvements in Hashimoto’s antibody levels
  • Better metabolic flexibility in thyroid patients
  • Potential reduction in future autoimmune risk

The panel also directly addresses concerns about thyroid cancer.

What Current Research Shows

The fear largely originated from rodent studies involving:

  • Extremely high doses
  • Rat thyroid tissue with dense GLP receptors

Current human data has not shown meaningful increased thyroid cancer risk.

In fact:
👉 Some studies suggest reductions in several cancer risks while using GLP-1s.

💪 Muscle Loss, Protein & Strength Training

One of the biggest concerns surrounding GLP-1s is muscle loss.

The panel makes an important distinction:

👉 Muscle loss is not inherently caused by the medication itself
👉 It is often caused by under-fueling and inadequate resistance training

The Real Problem

Some individuals:

  • Eat far too little
  • Avoid protein
  • Stop strength training
  • Lose weight too quickly

This creates:

  • Sarcopenia
  • Reduced metabolic health
  • Poor long-term outcomes

The Solution

According to Shannon Ritchey:

  • Lift heavy
  • Train close to muscular failure
  • Prioritize protein intake
  • Preserve and build muscle while losing fat

The panel strongly reinforces:

👉 Muscle is metabolic currency for women’s long-term health.

👶 Fertility, PCOS & Pregnancy

Natalie Crawford discusses the growing role of GLP-1s in fertility medicine.

Conditions Showing Promise

  • PCOS
  • Insulin resistance
  • Chronic inflammation
  • Endometriosis
  • Recurrent pregnancy loss

Why It Matters

Insulin resistance impacts:

  • Ovulation
  • Hormone production
  • Egg quality
  • Fertility treatment outcomes

Reducing inflammation and improving metabolic health may dramatically improve reproductive outcomes.

Important Safety Note

GLP-1s are not currently recommended during pregnancy.

Patients are advised to:
👉 Stop GLP-1 medications at least two months before attempting conception.

🌸 Perimenopause, Menopause & Hormonal Aging

Jessica Shepherd explains how declining estrogen impacts:

  • Glucose regulation
  • Inflammation
  • Visceral fat
  • Cardiovascular risk
  • Metabolic function

The panel highlights that menopause is:
👉 A whole-body hormonal transition—not just a reproductive event.

Why GLP-1s May Matter in Midlife

As estrogen declines:

  • Insulin resistance often worsens
  • Visceral fat increases
  • Inflammation rises

GLP-1s may help:

  • Improve metabolic function
  • Reduce inflammatory burden
  • Support healthier aging outcomes

❤️ Cardiovascular Health & Longevity

Another major theme:

👉 Cardiovascular disease remains the number one killer of women.

The panel discusses research showing GLP-1s may:

  • Reduce cardiovascular events
  • Improve inflammatory markers
  • Lower mortality risk

Potential Longevity Implications

Improved:

  • Insulin sensitivity
  • Metabolic function
  • Inflammatory regulation

…may contribute to:

  • Longer health span
  • Better aging outcomes
  • Reduced chronic disease risk

🍷 Addiction, Fatty Liver & Emerging Research

The discussion also touches on newer research areas.

Emerging Benefits Being Studied

  • Reduced alcohol cravings
  • Improved addictive behaviors
  • Better fatty liver disease outcomes
  • Improved sperm quality
  • Potential ovarian longevity benefits

The panel emphasizes:
👉 Research is still evolving, but the possibilities are significant.

🌱 Lifestyle Still Matters Most

Despite enthusiasm around GLP-1s, every panelist strongly reinforces:

👉 Medication is not a replacement for lifestyle.

Foundational habits remain critical:

  • Resistance training
  • Protein intake
  • Sleep
  • Stress management
  • Nutrition
  • Nervous system regulation

The medications work best when paired with:
👉 Sustainable lifestyle change.

🌟 Final Takeaway

This SXSW discussion makes one thing very clear:

GLP-1 medications may represent one of the most significant shifts in women’s health and metabolic medicine in decades.

But the future is not about:

  • Extreme restriction
  • Rapid weight loss
  • Chasing thinness

It’s about:

  • Reducing inflammation
  • Improving metabolic health
  • Preserving muscle
  • Supporting hormones
  • Increasing longevity
  • Helping women feel better in their bodies again

👥 Panelists

👩‍⚕️ McCall McPherson
📸 Instagram: McCall McPherson

👩‍⚕️ Natalie Crawford
📸 Instagram: Natalie Crawford MD

👩‍⚕️ Jessica Shepherd
📸 Instagram: Jessica Shepherd MD

🏋️‍♀️ Shannon Ritchey
📸 Instagram: Dr. Shannon Ritchey

📲 Follow McCall McPherson & Modern Thyroid and Wellness

💻 Website: modernthyroidclinic.com

🐦 X / Twitter: @thyroidexpert

🌐 Host Website: mccallmcpherson.com

📺 YouTube: McCall McPherson Channel

📘 Facebook: McCall McPherson PAC

📸 Instagram: @mccallmcphersonpa

‍

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Feeling Tired & Foggy? The Best Natural Fix for Energy, Detox & Hormone Health with Dr. Catharine Arnston

In this energizing episode, McCall McPherson is joined by Dr. Catharine Arnston, founder of Energy Bits, to uncover the powerful, science-backed health benefits of microalgae. What began as a personal mission—helping her sister navigate cancer treatment—turned into a 16-year journey into the world of spirulina and chlorella. Dr. Arnston explains how these superfoods support detoxification, boost cellular energy, and play a vital role in women’s health, particularly during perimenopause and menopause. Packed with actionable tips and nutritional insights, this conversation empowers listeners to explore natural solutions for longevity, beauty, and vibrant well-being.
July 17, 2025 2:00
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What Your Thyroid Labs Aren’t Telling You – The Root Cause Fix with Dr. Cassie Smith

In this enlightening episode, host McCall McPherson is joined by Dr. Cassie Smith, a dual board-certified endocrinologist and founder of Modern Endocrine, to discuss her powerful shift from conventional medicine to functional care. After struggling with autoimmune thyroid disease herself, Dr. Smith sought out a more comprehensive, patient-centered approach to healing.
July 3, 2025 5:15
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What the Health Industry Isn’t Telling You – Transparency & Healing with Dr. Christina Rahm

In this empowering episode, McCall McPherson is joined by Dr. Christina Rahm, a renowned health entrepreneur and humanitarian who shares her deeply personal journey of overcoming Lyme disease and cancer. These life-altering experiences became the catalyst for her groundbreaking work in wellness innovation, leading to the development of science-backed detoxification and healing solutions. Dr. Rahm opens up about the challenges of being a female leader in a male-dominated health industry and her ongoing mission to uplift and empower women around the world. The episode dives into safe detox practices, industry transparency, and the values of collaboration, integrity, and holistic care in transforming individual and community health.
June 26, 2025 8:18
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Inflammation, Be Gone! – The Fastest Way to Heal with Nano Bubble Oxygen Therapy with Jason Applewhite

In this episode, host McCall McPherson shares a powerful personal story about her daughter’s health transformation through the use of Bimini Hydrotherapy’s oxygen nano bubble technology. She’s joined by Jason Applewhite, co-founder of Bimini, who breaks down how their patented Nano Jet system supports faster recovery, reduces inflammation, and enhances overall well-being. Whether you’re an athlete or navigating a chronic condition, this episode offers insight into an emerging wellness technology with the potential to revolutionize healing and longevity.
June 19, 2025 6:23
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Can Your Body Heal Itself? – The Best Natural Stem Cell Solution with Ryan Riley

In this episode, host Mccall speaks with Ryan Riley, CEO of Stemregen, about the company’s innovative stem cell support products and holistic health programs. They discuss the science behind activating the body’s own stem cells, share promising anecdotal and preliminary study results for conditions like heart failure and Parkinson’s, and explore the “More You 60 Day Challenge,” which integrates physical, emotional, and spiritual healing. Mccall also shares her personal connection to the topic through her daughter Rosie, highlighting the potential impact of these approaches for families facing health challenges.
June 12, 2025 5:16
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Unlocking the Gut-Body Connection: The Surprising Links Between Digestion, Immunity & Mental Health

In this podcast episode, host McCall McPherson is joined by two industry-leading guests in the microbiome and wellness space: Tina Anderson, CEO and Co-Founder of Just Thrive Probiotic & Antioxidant, and Kiran Krishnan, Microbiologist and Co-Founder of Microbiome Labs. Together, they dive into the critical role gut health plays in thyroid function, immune resilience, and mental clarity—especially in the context of autoimmune conditions like Hashimoto’s. From the impact of environmental toxins and stress to the unique benefits of spore-based probiotics, this conversation demystifies the gut-thyroid connection and offers practical, science-backed solutions for healing and thriving.
June 5, 2025 11:19
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The Missing Link in Thyroid Healing – Adrenal Truths with McCall McPherson

In this podcast episode, McCall McPherson explores the crucial connection between adrenal function and thyroid conditions. She explains the role of the adrenal glands in managing stress and underscores the importance of maintaining adrenal health. Symptoms of adrenal dysfunction, such as fatigue and brain fog, are discussed, highlighting their overlap with thyroid issues.
May 22, 2025 10:50
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The Truth About GLP-1s, Thyroid Meds & Hormone Therapy – Real Answers with McCall McPherson

In this podcast episode, McCall McPherson delves into health topics like GLP-1 medications, thyroid health, and hormone therapy, answering listener questions from Instagram. McCall discusses the benefits and side effects of GLP-1 medications for weight loss, emphasizing personalized dosing to minimize adverse reactions. She also addresses thyroid health, particularly the challenges of discontinuing thyroid medications and the importance of proper management. The episode covers hormone therapy, including testosterone and estrogen treatments, and highlights the significance of individualized care. Personal anecdotes and professional insights make the episode an engaging resource for those interested in health and wellness.
May 15, 2025 5:26
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Rethinking Breast Cancer – The Holistic Truth Doctors Don’t Tell You with Dr. Jen Simmons

In this episode, McCall McPherson introduces Dr. Jen Simmons, a former breast cancer surgeon who has transitioned into an integrative oncologist. Dr. Simmons shares her personal journey, highlighting her family's history with breast cancer and her own diagnosis, which prompted her to question conventional treatments. She underscores the limitations of traditional cancer therapies and advocates for a holistic approach that addresses the root causes of disease. Dr. Simmons discusses her book, The Smart Woman's Guide to Breast Cancer, and her programs focused on prevention and health restoration. The episode calls for a paradigm shift in breast cancer care, promoting integrative and functional medicine.
May 1, 2025 5:05
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The Science of Younger Skin – How One Peptide is Changing the Game with Alessandra Zonari

In this episode, host McCall McPherson, a dedicated user of One Skin products, interviews Alessandra Zonari, co-founder and Chief Scientific Officer of One Skin. Alessandra, who holds a PhD in skin regeneration, delves into the science of skin aging, particularly focusing on senescent cells and inflammation.
April 22, 2025 8:33
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The Shocking Truth About Bone Loss – How to Rebuild Strength with Kevin Ellis, The Bone Coach

In this podcast episode, host McCall McPherson engages with Kevin Ellis, "The Bone Coach," who shares his journey from a Marine to a bone health advocate after being diagnosed with osteoporosis at a young age. Kevin discusses osteopenia and osteoporosis, emphasizing the importance of understanding bone density and turnover markers.
April 15, 2025 9:33
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The Truth About Biological Age – What Really Slows Aging with Dr. Matt Kaeberlein

In the final episode of our three-part series on longevity, we had the pleasure of speaking with Dr. Matt Kaeberlein, the Chief Executive Officer of Optus Span Inc., an affiliate professor at the University of Washington, and a co-founder of the Dog Aging Project. Dr. Kaeberlein's work focuses on the biological processes underlying aging and age-related diseases, offering a fresh perspective on how we can enhance both human and animal health. This blog post delves into the key themes discussed in the episode, providing actionable advice and detailed insights into the science of biological aging.
April 18, 2025 9:54
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The Molecule That Could Slow Aging – NAD Breakthroughs with Dr. Joseph A. Baur

In this podcast episode, the host delves into the fascinating subject of longevity and healthspan with Dr. Joseph A. Baur, a renowned expert in NAD (nicotinamide adenine dinucleotide) research. Dr. Baur elucidates the critical role of NAD in cellular metabolism, aging, and energy production.
April 3, 2025 9:46
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The Longevity Switch in Your Cells – Unlocking mTOR for a Healthier Life with Dr. Dudley Lamming

In the latest episode of our podcast, we delve into the fascinating world of mTOR (mechanistic target of rapamycin), a crucial protein that plays a significant role in regulating cellular processes related to growth, metabolism, and aging. The discussion is led by our host, who introduces the topic and welcomes Dr. Dudley Lamming, a prominent researcher in the field of aging and metabolism. Dr. Lamming serves as an associate professor and vice chair for biomedical research at the University of Wisconsin's Department of Medicine, where he focuses on the biology of aging and its implications for health and longevity.
March 25, 2025 15:41
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The Secret to Aging Powerfully – Build Strength & Longevity with JJ Virgin

The Secret to Aging Powerfully – Build Strength & Longevity with JJ Virgin
March 10, 2025 10:28
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Managing PCOS: A Holistic Approach to Hormonal Health

March 3, 2025 11:09
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Advancing Thyroid Care: Minimally Invasive Treatments with Jonathon O. Russell

Advancements in Thyroid Health: Exploring Radiofrequency Ablation (RFA) and Scarlett's Thyroid Surgery
February 28, 2025 17:05
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The Modern Thyroid Clinic: Revolutionizing Thyroid Care

In this podcast episode, a healthcare professional, likely a physician assistant (PA) or doctor, shares their personal journey with thyroid dysfunction ....
February 17, 2025 16:44
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Understanding Pelvic Floor Health: Insights from the "Vagina Coach"

Pelvic floor health is a critical yet often overlooked aspect of women's health, especially as they age. In this podcast episode, ....
February 16, 2025 9:58
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Breakthrough in Testosterone Therapy: A Deep Dive into Kaiser Trax

In this episode of the podcast, host McCall McPherson engages in a compelling discussion with Shalin Shah, the CEO of Marius Pharmaceuticals, about a significant ....
February 16, 2025 9:58
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Exploring Health and Wellness: Insights from a Casual Chat in Sicily

In this podcast episode, the host, McCall McPherson, delves into a variety of health topics, sharing personal experiences and answering ....
February 16, 2025 9:54
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Unlocking the Potential of Stem Cells: Insights from Dr. Nathan Newman on "Modern Thyroid and Wellness"

In this episode of "Modern Thyroid and Wellness," host McCall McPherson delves into the transformative world of stem cells ....
February 16, 2025 9:58
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Fertility, Pregnancy, and Postpartum Health: The Role of Thyroid Hormones

In this episode, we delve into a highly requested topic: fertility, pregnancy, and postpartum health, with a particular focus on the critical role ....
February 16, 2025 9:59
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The Power of Strength Training for Women: Insights from Dr. Shannon Ritchey

In this episode of our podcast, we had the pleasure of hosting Dr. Shannon Ritchey, a former physical therapist, fitness trainer, ....
February 16, 2025 9:59
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Comprehensive Guide to Women's Hormonal Health and Longevity with Dr. Amy Killen

In this podcast episode, the host welcomed Dr. Amy Killen, a renowned physician specializing in longevity and regenerative medicine ....
February 16, 2025 9:59
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Thriving During the Holiday Season: A Comprehensive Guide to Health and Well-Being

The holiday season, while joyous, often brings a unique set of challenges that can impact our health and well-being. From managing stress ....
February 16, 2025 9:48
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Navigating Thyroid Medications: Insights from McCall McPherson

In this episode of "Modern Thyroid and Wellness," host McCall McPherson dives deep into the intricacies of thyroid medications, focusing on the differences between T4 ...
February 16, 2025 9:47
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Understanding Breast Implant Illness: Insights from Dr. Rob Whitfield on the "Modern Thyroid and Wellness" Podcast

In this episode of the "Modern Thyroid and Wellness" podcast, host McCall McPherson engages in a deep and enlightening conversation ....
February 16, 2025 9:46
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Is Your Thyroid Health Holding You Back from Living Your Best Life?

In this episode of our podcast, we had the pleasure of hosting Gina, an intuitive healer and spiritual coach, who shared ....
February 17, 2025 16:44
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Understanding Hormonal Health in Women with Thyroid Disorders: Insights from McCall McPherson

In this episode of the "Modern Thyroid and Wellness" podcast, host McCall McPherson delves into the intricate relationship ....
February 16, 2025 9:59
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Debunking Myths About GLP-1 Medications: A Comprehensive Guide

In this episode of our podcast, we delve into the fascinating world of GLP-1 medications, exploring their benefits, mechanisms, ....
February 16, 2025 9:59
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The Overlooked Importance of Air Quality: Insights from the "Modern Thyroid and Wellness" Podcast

In this episode of the "Modern Thyroid and Wellness" podcast, host McCall McPherson and guest Mike Feldstein delve into the often-rejected topic of air quality and ....
February 16, 2025 9:59
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The Greatest Turnaround: Jacinda’s Inspiring Weight Loss and Health Transformation

In this episode of our podcast, we had the pleasure of speaking with Jacinda, a patient at the Modern Thyroid Clinic and a participant ....
February 16, 2025 9:42
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GLP-1 Agonists: The Medical Revolution Beyond Weight Loss with Sally Sykes

In this podcast episode, the host from Modern Thyroid Clinic and Modern Weight Loss introduces Sally Sykes, a former attorney ....
February 16, 2025 10:00
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The Hidden Connection Between Thyroid Health and Mental Well-Being

In this episode,McCall McPherson from the Modern Thyroid Clinic and Ainslee, a patient, discuss Ainslee's transformative journey ....
February 16, 2025 10:00
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GLP-1 Agonists: The Medical Revolution Beyond Weight Loss

In this podcast episode, McCall McPherson, a medical professional from the Modern Thyroid Clinic, explores the benefits of GLP-1 agonists, originally developed for diabetes ....
February 16, 2025 10:00
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Graves and Hyperthyroidism Uncovered!

In this podcast episode, McCall McPherson explores the complexities of Graves' disease and hypothyroidism ....
February 16, 2025 10:00
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The Best Strategies for Reducing Thyroid

Hashimoto's disease is an autoimmune condition where the immune system mistakenly attacks the thyroid gland ....
February 17, 2025 16:44
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Is Your Thyroid Really the Problem?

In this enlightening episode, we delve into the complexities of thyroid disorders, focusing on why many patients, ....
February 17, 2025 16:44
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Unmasking the Thyroid: Your Journey to Wellness Starts Here!

In this episode, your host McCall McPherson, a Physician Assistant and Thyroid Expert, shares her personal and professional journey with thyroid conditions, including hypothyroidism ....
February 16, 2025 9:39
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